The significance of Rb-gene protein expression in gastric cancers and adjacent tissue of gastric carcinoma

Objectives To detect the expression and distribution of Rb-gene protein in adjacent tissue of cancers and gastric carcinoma tissues.Methods The expression of Rb protein were observed in 88 cases of gastric cancer and 52 cases adjacent tissue of cancers by S-P immunohistochemistry.Results The expression of Rb gene pootein were observed in gastric carcinoma tissues and adjacent tissues of cancers.The positive expression of Rb were 61.36% and 84.61% , The brown granules of positive cell were mainly distributed in the nucleolus. Rb-gene protein expression were not related to age, sex and tumor position, but were significantly correlated with histological type, invasion depth, lymph node metastasis and clinical pathological stage.Conclusions The loss of Rb-gene and the change of its expression level are correlated with gastric cancer and the check of its expression can be used as an independently index to evaluate the biological behavior and prognosis of gastric cancer.