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2003•The Chinese Journal of Modern Applied PharmacyRequires access

Studies on the dissolution profile of phosphate tetramethylpyrazine sustained-release pellets coated with eudragit pseudolatex

Yu Zhang

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Abstract

OBJECTIVE To study the dissolution profile of phosphate tetramethylpyrazine sustained release pellets coated with Eudragit pseudolatex. METHOD The Phosphate Tetramethylpyrazine sustained release pellets were coated with the mixture of Eudragit RL30D and Eudragit RS30D. The effects of the Eudragit RL30D/Eudragit RS30D ratio?coating level or different pH value of the dissolution medium on the drug releasing rate from the pellets were observed.RESULTS With the increasing of Eudragit RL30D/Eudragit RS30D ratio?decreasing of coating level or increasing of the pH value of disslution medium, the drug release from the pellets was increased.CONCLUSION The ratio of Eudragit RL30D/Eudragit RS30D ratio?coating level or different pH value of the dissolution medium significantly influenced phosphate tetramethylpyrazine release from sustained pellets.

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What this paper is about

OBJECTIVE To study the dissolution profile of phosphate tetramethylpyrazine sustained release pellets coated with Eudragit pseudolatex. METHOD The Phosphate Tetramethylpyrazine sustained release pellets were coated with the mixture of Eudragit RL30D and Eudragit RS30D. The effects of the Eudragit RL30D/Eudragit RS30D ratio?coating level or different pH value of the dissolution medium on the drug releasing rate from the pellets were observed.RESULTS With the increasing of Eudragit RL30D/Eudragit RS30D ratio?decreasing of coating level or increasing of the pH value of disslution medium, the drug release from the pellets was increased.CONCLUSION The ratio of Eudragit RL30D/Eudragit RS30D ratio?coating level or different pH value of the dissolution medium significantly influenced phosphate tetramethylpyrazine release from sustained pellets.

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Available abstract

OBJECTIVE To study the dissolution profile of phosphate tetramethylpyrazine sustained release pellets coated with Eudragit pseudolatex. METHOD The Phosphate Tetramethylpyrazine sustained release pellets were coated with the mixture of Eudragit RL30D and Eudragit RS30D. The effects of the Eudragit RL30D/Eudragit RS30D ratio?coating level or different pH value of the dissolution medium on the drug releasing rate from the pellets were observed.RESULTS With the increasing of Eudragit RL30D/Eudragit RS30D ratio?decreasing of coating level or increasing of the pH value of disslution medium, the drug release from the pellets was increased.CONCLUSION The ratio of Eudragit RL30D/Eudragit RS30D ratio?coating level or different pH value of the dissolution medium significantly influenced phosphate tetramethylpyrazine release from sustained pellets.

Key concepts: Tetramethylpyrazine, Pellets, Dissolution, Phosphate, Coating, Nuclear chemistry, Chemistry, Chromatography

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Studies on the dissolution profile of phosphate tetramethylpyrazine sustained-release pellets coated with eudragit pseudolatex — Research Paper | ScholarLens