2006•Zhongguo xin yao zazhiRequires access
Preparation of metoprolol tartrate sustained-release pellets
Xingguo Mei
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Abstract
Objective:To optimize the formulation of metoproiol tartrate sustained release pellets coated with mixed Eudragit RS 30D and Eudragit RL 30D.Methods:Metoprolol tartrate pellets were prepared by Glatt fluid bed technique.The ratio of Eudragit RS 30D to Eudragit RL 30D(2:3,7:3 and 9:1,w/w)in the formulation was optimized.The factors to influence the drug release behaviors,such as loading weight of copolymers Eudragit RS 30D and Eudragit RL 30D(10%,20% and 30%,w/w), plasticizer concentration(10%,20% and 40%)and storage time,were evaluated.Results:The opti- mal drug sustained-release was shown at the ratio of Eudragit RS 30D to Eudragit RL 30D of 9:1,the loading weight of copolymers of 20% and the plasticizer concentration of 20%.Conclusion:The optimal sustained release of the metoprolol tartrate pellets is featured by adjusting the ratio of Eudragit RS 30D to Eudragit RL 30D.