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2004•Chinese Journal of New Drugs and Clinical RemediesRequires access

Quetiapine (35 patients) vs chlorpromazine (34 patients) in treatment of schizophrenia

Wang Laihai

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Abstract

AIM: To compare the therapeutic efficacy and adverse reactions of quetiapine and chlorpromazine in the treatment of schizophrenia. METHODS: Sixty-nine patients were divided into two groups: quetiapine-treated group (n=35; M 18, F 17) and chlorpromazine-treated group (n=34; M 19, F15). The dosage of drug administration in two groups was both 200-600 mg·d -1 and the treatment duration was 12 wk. The efficacy and adverse reactions were assessed by the PANSS and TESS, respectively. RESULTS: The clinical effective rate was 66 % in quetapine group and 65 % in chlorpromazine group, there was no significant difference between two groups (P0.05). But compared with quetiapine group, the adverse reactions in chlorpromazine group occurred more often. CONCLUSION: The clinical efficacy of quetiapine and chlorpromazine in treating schizophrenia is similar, and adverse reactions of the former are lower than that of the latter.

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AIM: To compare the therapeutic efficacy and adverse reactions of quetiapine and chlorpromazine in the treatment of schizophrenia. METHODS: Sixty-nine patients were divided into two groups: quetiapine-treated group (n=35; M 18, F 17) and chlorpromazine-treated group (n=34; M 19, F15). The dosage of drug administration in two groups was both 200-600 mg·d -1 and the treatment duration was 12 wk. The efficacy and adverse reactions were assessed by the PANSS and TESS, respectively. RESULTS: The clinical effective rate was 66 % in quetapine group and 65 % in chlorpromazine group, there was no significant difference between two groups (P0.05). But compared with quetiapine group, the adverse reactions in chlorpromazine group occurred more often. CONCLUSION: The clinical efficacy of quetiapine and chlorpromazine in treating schizophrenia is similar, and adverse reactions of the former are lower than that of the latter.

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Available abstract

AIM: To compare the therapeutic efficacy and adverse reactions of quetiapine and chlorpromazine in the treatment of schizophrenia. METHODS: Sixty-nine patients were divided into two groups: quetiapine-treated group (n=35; M 18, F 17) and chlorpromazine-treated group (n=34; M 19, F15). The dosage of drug administration in two groups was both 200-600 mg·d -1 and the treatment duration was 12 wk. The efficacy and adverse reactions were assessed by the PANSS and TESS, respectively. RESULTS: The clinical effective rate was 66 % in quetapine group and 65 % in chlorpromazine group, there was no significant difference between two groups (P0.05). But compared with quetiapine group, the adverse reactions in chlorpromazine group occurred more often. CONCLUSION: The clinical efficacy of quetiapine and chlorpromazine in treating schizophrenia is similar, and adverse reactions of the former are lower than that of the latter.

Key concepts: Quetiapine, Chlorpromazine, Adverse effect, Schizophrenia (object-oriented programming), Medicine, Clinical efficacy, Drug reaction, Anesthesia

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