Effect of small dose of droperidol combined with dexamethasone in preventing PONV after pediatric laparoscopic operation

Objective To observe the effect of small dose of droperidol combined with dexamethasone in preventing PONV after pediatric laparoscopic operation and the occurrence of complications. Methods 200 pediatric patients scheduled for laparoscopic surgeries of hernia and cryptorchidism decline fixation( 1- 4 years old,ASA status I- II),were randomly assigned into four groups( A: droperidol group,B: dexamethasone group,C: droperidol combined with dexamethasone group,D: control group). Anesthesia induced by propofol 2mg / kg,fentanyl 3ug / kg,cisatracurium 0. 12 mg / kg,and maintained with intravenous inhalational anesthesia. At the beginning of surgeries,droperidol( 25 ug / Kg) was administrated in group A,dexamethasone( 0. 1mg / kg) in group B,and droperidol( 25 ug / Kg) combined with dexamethasone( 0. 1mg / kg) in group C. Postoperative analgesia was performed with fentanyl( 0. 01 ug / kg / min). PONV and other complications were observed and documented. Results Incidence of PONV in group D was significantly higher comparing with other groups( P 0. 05). Incidence of PONV in group C was significantly lower comparing with group A and B( P 0. 05),there was no statistically differences between group A and B. Conclusions Small dose of droperidol combined with dexamethasone can significantly prevent occurrence of PONV after pediatric laparoscopic operation.