Levels of proadrenomedullin N terminal 20 peptide in patients with coronary disease and the changes after coronary circulation

Objective:To investigate the levels of proadrenomedullin N terminal 20 peptide(PAMP)in patients with coronary heart disease(CHD)and the changes after coronary circulation in patients with CHD.Method:The 64 patients with coronary heart disease were studied.Blood samples were collected during percutaneous coronary intervention(PCI) from peripheral circulation、 aortic root(Ao) and coronary sinus(CS),and the concentrations of PAMP were measured respectively.The sino-arterial(CS-Ao) difference was measured as cardiac PAMP.Result:The concentration of PAMP in patients with CHD increase significantly in peripheral circulation and coronary sinus,and the concentration of PAMP in coronary sinus were higher than peripheral circulation and aorta (P0.01),The CS-Ao differences of PAMP in CHD were much higher than control groups(P0.01).The significant positive correlation among peripheral circulation,coronary sinus.Conclusion:PAMP may be involved in the process of pathophysiology in patients with coronary disease and may be one of the protective mechanisms to the stabilization of organism internal environment.These results indicate PAMP may be one of the important vasoactive substances in the process of CHD.