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2011•Nuclear TechniquesRequires access

Synthesis and radiolabelling of ~(188)Re labeled dendrimer PAMAM-folic acid conjugate

Cui Wei, Yuanqing Zhang, Xiaoping Xu

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Abstract

Folic acid receptor(FR) was usually overexpressed in many cancer cells and was considered as potential target for targeted therapy agent.We decorated dendrimer polyamidoamine generation five-folic with acid and 1B4M-DTPA and then radiolabeled with ~(188)Re.Thes in vitro stability was evaluated.The labeling yield of the G5-FA-DTPA-~(188)Re was 67.5%,with a radiochemical purity of over 95%.The conjugate also showed high in vitro stability.Further modifications on the dendrimer folic acid conjugate and biological evaluation is in progress and will be reported in due course.

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What this paper is about

Folic acid receptor(FR) was usually overexpressed in many cancer cells and was considered as potential target for targeted therapy agent.We decorated dendrimer polyamidoamine generation five-folic with acid and 1B4M-DTPA and then radiolabeled with ~(188)Re.Thes in vitro stability was evaluated.The labeling yield of the G5-FA-DTPA-~(188)Re was 67.5%,with a radiochemical purity of over 95%.The conjugate also showed high in vitro stability.Further modifications on the dendrimer folic acid conjugate and biological evaluation is in progress and will be reported in due course.

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Available abstract

Folic acid receptor(FR) was usually overexpressed in many cancer cells and was considered as potential target for targeted therapy agent.We decorated dendrimer polyamidoamine generation five-folic with acid and 1B4M-DTPA and then radiolabeled with ~(188)Re.Thes in vitro stability was evaluated.The labeling yield of the G5-FA-DTPA-~(188)Re was 67.5%,with a radiochemical purity of over 95%.The conjugate also showed high in vitro stability.Further modifications on the dendrimer folic acid conjugate and biological evaluation is in progress and will be reported in due course.

Key concepts: Conjugate, Dendrimer, Folic acid, Chemistry, In vitro, Folate receptor, Yield (engineering), Combinatorial chemistry

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Synthesis and radiolabelling of ~(188)Re labeled dendrimer PAMAM-folic acid conjugate — Research Paper | ScholarLens