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2010•Chinese Journal of ChemistryRequires access

Synthesis, Radiolabelling and in vitro Stability Study of 99mTc(CO)+3 Labeled Dendrimer PAMAM‐Folic Acid Conjugate

Yuanqing Zhang, Xiaoping Xu, Yanhong Sun, Yu‐Mei Shen

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Abstract

Abstract Dendrimer polyamidoamine generation five‐folic acid conjugate was synthesesed and radiolabelled with fac‐[99mTc(CO)3(H2O)3]+, its in vitro stability was evaluated further. Both of the labeling yield and radiochemical purity of the G5‐FA‐DTPA‐99mTc(CO)3 conjugate exceeded 95%. More than 95.7% and 93.1% of the conjugate still keeps its original structure in PBS and new‐born calf serum solution respectively.

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What this paper is about

Abstract Dendrimer polyamidoamine generation five‐folic acid conjugate was synthesesed and radiolabelled with fac‐[99mTc(CO)3(H2O)3]+, its in vitro stability was evaluated further. Both of the labeling yield and radiochemical purity of the G5‐FA‐DTPA‐99mTc(CO)3 conjugate exceeded 95%. More than 95.7% and 93.1% of the conjugate still keeps its original structure in PBS and new‐born calf serum solution respectively.

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Available abstract

Abstract Dendrimer polyamidoamine generation five‐folic acid conjugate was synthesesed and radiolabelled with fac‐[99mTc(CO)3(H2O)3]+, its in vitro stability was evaluated further. Both of the labeling yield and radiochemical purity of the G5‐FA‐DTPA‐99mTc(CO)3 conjugate exceeded 95%. More than 95.7% and 93.1% of the conjugate still keeps its original structure in PBS and new‐born calf serum solution respectively.

Key concepts: Conjugate, Chemistry, Dendrimer, Yield (engineering), In vitro, Radiochemistry, Folic acid, Nuclear chemistry

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