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2010•Medical Journal of Chinese People's HealthRequires access

Comparative study of Duloxetine and Citalopram in the treatment of senile depression

Weijuan Wu

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Abstract

Objective:To compare the efficacy and safety of Duloxetine and Citalopram in the treatment of senile depression. Methods:66 patients with senile depression were randomly divided into Duloxetine group and Citalopram group for 6 week treatment. Hamilton depression scale (HAMD) and treatment emergent symptom scale (TESS) were used to evaluate the clinical efficacy and safety, before treatment and 1, 2, 4,6week after treatment.Results: The score of HAMD reduced significantly after every treatment time in two groups (both P0.01). There were no significant differences in the efficacy and adverse events between the two groups.Conclusions: Duloxetine is an effective and safe antidepressant in the treatment of senile depression.

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What this paper is about

Objective:To compare the efficacy and safety of Duloxetine and Citalopram in the treatment of senile depression. Methods:66 patients with senile depression were randomly divided into Duloxetine group and Citalopram group for 6 week treatment. Hamilton depression scale (HAMD) and treatment emergent symptom scale (TESS) were used to evaluate the clinical efficacy and safety, before treatment and 1, 2, 4,6week after treatment.Results: The score of HAMD reduced significantly after every treatment time in two groups (both P0.01). There were no significant differences in the efficacy and adverse events between the two groups.Conclusions: Duloxetine is an effective and safe antidepressant in the treatment of senile depression.

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Available abstract

Objective:To compare the efficacy and safety of Duloxetine and Citalopram in the treatment of senile depression. Methods:66 patients with senile depression were randomly divided into Duloxetine group and Citalopram group for 6 week treatment. Hamilton depression scale (HAMD) and treatment emergent symptom scale (TESS) were used to evaluate the clinical efficacy and safety, before treatment and 1, 2, 4,6week after treatment.Results: The score of HAMD reduced significantly after every treatment time in two groups (both P0.01). There were no significant differences in the efficacy and adverse events between the two groups.Conclusions: Duloxetine is an effective and safe antidepressant in the treatment of senile depression.

Key concepts: Duloxetine, Citalopram, Hamd, Depression (economics), Antidepressant, Clinical efficacy, Medicine, Internal medicine

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