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2010•Journal of International PsychiatryRequires access

Comparative study of duloxetine and citalopram in the treatment of senile depresson

Xie Ru

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Abstract

Objective To compare clinical efficacy and safety of between duloxetine and citalopram in the treatment of senile depression.Methods 29 patients were randomly divided into duloxetine group(n=29) and citalopram group(n=29) for 8 weeks.Hamilton rating scale for depression(HAMD)、Hamilton rating scale for anxiety(HAMA) and treatment emergent symtom scale(TESS)were used to evaluate the efficacy and side effects respectively.Results There were no significant difference in efficacy at the end of 8th weeks(P0.05) between 2 groups.There were no significant difference in side effect between these two groups.Conclusion Duloxetine is an safe and effecfive antidepressant in the treatment of senile depression.

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Objective To compare clinical efficacy and safety of between duloxetine and citalopram in the treatment of senile depression.Methods 29 patients were randomly divided into duloxetine group(n=29) and citalopram group(n=29) for 8 weeks.Hamilton rating scale for depression(HAMD)、Hamilton rating scale for anxiety(HAMA) and treatment emergent symtom scale(TESS)were used to evaluate the efficacy and side effects respectively.Results There were no significant difference in efficacy at the end of 8th weeks(P0.05) between 2 groups.There were no significant difference in side effect between these two groups.Conclusion Duloxetine is an safe and effecfive antidepressant in the treatment of senile depression.

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Available abstract

Objective To compare clinical efficacy and safety of between duloxetine and citalopram in the treatment of senile depression.Methods 29 patients were randomly divided into duloxetine group(n=29) and citalopram group(n=29) for 8 weeks.Hamilton rating scale for depression(HAMD)、Hamilton rating scale for anxiety(HAMA) and treatment emergent symtom scale(TESS)were used to evaluate the efficacy and side effects respectively.Results There were no significant difference in efficacy at the end of 8th weeks(P0.05) between 2 groups.There were no significant difference in side effect between these two groups.Conclusion Duloxetine is an safe and effecfive antidepressant in the treatment of senile depression.

Key concepts: Duloxetine, Hamd, Citalopram, Rating scale, Antidepressant, Depression (economics), Escitalopram, Psychology

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