Predictive risk factors for multiple intracranial aneurysms rupture

Objective To analyze the risk factors inducing the rupture of multiple intracranial aneurysms. Methods Between July 2007 and July 2011, a total of 134 patients with 294 aneurysms were admitted to the hospital. Of the 294 aneurysms, 50 were ruptured and 244 were unruptured. Every patient had two or more aneurysms. Univariate and multivariate logistic regression analysis methods were used to analyze the risk factors, including age, gender, site and size, for multiple intracranial aneurysms. Results The 134patients were divided into three groups according to patient's age, including 45 group,(45-65) group and 65 group. The rupture incidence of aneurysm in the(45-65) group was highest in the three groups.The difference was significant(P = 0.001). Of 35 patients with anterior communicating arterial aneurysms, 13(37.1%) were ruptured, accounting for 26% of all ruptured aneurysms, and the rupture rate of anterior communicating arterial aneurysms was significantly higher than that of the aneurysms located at other sites(P =0.001). Of all 294 aneurysms, 88.1% were 5 mm, 58.2% were 3 mm. Of the ruptured aneurysms, 68%were 5 mm. Conclusion This study indicates that the rupture of multiple intracranial aneurysm is closely related to the patient's age, the size and location of aneurysm. Therefore, patient's age, the size and location of aneurysm should be taken into consideration when to make the therapeutic plan. In multiple intracranial aneurysms, the anterior communicating arterial aneurysm is most prone to bleeding.