Relationship between plasma N-terminal pro-brain natriuretic peptide and the short-term prognosis of acute myocardial infarction

Objective: To investigate the short-term prognostic value of plasma Nterminal pro-brain natriuretic peptide(NT-proBNP) on acute myocardial infarction.Method: A total of 132 subjects,including 30 healthy subjects and 102 patients with a first AMI were selected into the study.The plasma NT-proBNP was measured at 48 to 96 hours after infarction.Total mortality and the risk for major adverse cardiac events(MACE,including death,recurrent MI,recurrent angina,heart failure,readmission for any reason) were analyzed.Results: Six months later,plasma NT-proBNP was much higher in patients with AMI than that in health controls(326.1±193.4 pmol/L vs 73.5±58.3(pmol/L,) P0.01).With the increasing of NT-proBNP,the 6-month mortality and the incidence of MACE had been raising.Multivariate logistic regression analyses showed that the plasma NT-proBNP concentration predicted 6-month mortality((r=)0.943?7,P0.01)and incidence of MACE(r=0.607?2,P0.01).Conclusion: The plasma NT-proBNP level has relation with short-term prognosis of AMI.