Correlation between imipenem consumption and imipenem resistance in Klebsiella pneumoniae

Objective To evaluate the relationship between consumption of imipenem and imipenem resistance in Klebsiella pneumoniae(K.pneumoniae).Methods Imipenem resistance in K.pneumoniae isolated from all patients in a hospital from2008 to 2012 were analyzed,the amount of imipenem consumption during the same period was also calculated,and the correlation was analyzed.Results The clinical isolates of K.pneumoniae from2008 to2012 were 174,187,363,290,and 625 respectively,which accounting for 6.88%,7.86%,10.01%,8.07% and11.05% of all pathogens(χ2=16.516,P0.001).Resistant rate of K.pneumoniae to imipenem from2008—2012was 0.00%,0.00%,4.13%,10.34%,and 25.44%respectively,Cochran-Armitage trend test revealed a significant difference among them(Z=12.563,P0.001),namely imipenem resistance in K.pneumoniae increased year by year;annual consumption of imipenem from2008-2012 were 1.24,1.60,2.14,2.78,and 3.71 daily defined doses/1000 patient day,there was a increased tendency in imipenem resistance;imipenem consumption had positive correlation with imipenem resistance in K.pneumoniae(R=0.966,P=0.007).Conclusion Resistance rate of K.pneumoniaeto imipenem increased year by year from2008to 2012,which is related to the consumption of imipenem,it is important to monitor the antimicrobial resistance in K.pneumoniae and use imipenem and other carbapenems rationally.