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STUDY ON THE PHARMACOKINETICS OF BAICALIN IN NEW SAN-HUANG TABLET IN RATS

Liu Cui-zhe

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Abstract

Objective:To establish research methods on pharmacokinetics in vivo of baicalin in new San-huang tablet in rats.Methods:Male Wistar rats were lavaged with new San-huang tablets in dose of 1650mg/ kg(equivalent 200mg/kg baicalin).RP-HPLC was used to determine the baicalin content in rats’ plasma at different time after administration.3p97 software was used to deal with data of medicine concentration in plasma and calculate pharmacokinetic parameter for baicalin in rats.Results:The linear range of baicalin was 0.32μg/ml-6.4μg/ml.The absorption of baicalin in San-huang tablets in rats consistent with two-compartment model.The pharmacokinetic parameters of baicalin were T1/2(α)272min,T1/2(β)353min,T1/2(ka)102.1min,AUC 1431.9μg.min/ml,V 584ml and CL(s)1.15.Conclusions:The method is simple,sensitive and operated easily.It can be used to study the pharmacokinetic of baicalin in new San-huang tablet.

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Objective:To establish research methods on pharmacokinetics in vivo of baicalin in new San-huang tablet in rats.Methods:Male Wistar rats were lavaged with new San-huang tablets in dose of 1650mg/ kg(equivalent 200mg/kg baicalin).RP-HPLC was used to determine the baicalin content in rats’ plasma at different time after administration.3p97 software was used to deal with data of medicine concentration in plasma and calculate pharmacokinetic parameter for baicalin in rats.Results:The linear range of baicalin was 0.32μg/ml-6.4μg/ml.The absorption of baicalin in San-huang tablets in rats consistent with two-compartment model.The pharmacokinetic parameters of baicalin were T1/2(α)272min,T1/2(β)353min,T1/2(ka)102.1min,AUC 1431.9μg.min/ml,V 584ml and CL(s)1.15.Conclusions:The method is simple,sensitive and operated easily.It can be used to study the pharmacokinetic of baicalin in new San-huang tablet.

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Available abstract

Objective:To establish research methods on pharmacokinetics in vivo of baicalin in new San-huang tablet in rats.Methods:Male Wistar rats were lavaged with new San-huang tablets in dose of 1650mg/ kg(equivalent 200mg/kg baicalin).RP-HPLC was used to determine the baicalin content in rats’ plasma at different time after administration.3p97 software was used to deal with data of medicine concentration in plasma and calculate pharmacokinetic parameter for baicalin in rats.Results:The linear range of baicalin was 0.32μg/ml-6.4μg/ml.The absorption of baicalin in San-huang tablets in rats consistent with two-compartment model.The pharmacokinetic parameters of baicalin were T1/2(α)272min,T1/2(β)353min,T1/2(ka)102.1min,AUC 1431.9μg.min/ml,V 584ml and CL(s)1.15.Conclusions:The method is simple,sensitive and operated easily.It can be used to study the pharmacokinetic of baicalin in new San-huang tablet.

Key concepts: Baicalin, Pharmacokinetics, Pharmacology, Absorption (acoustics), Medicine, High-performance liquid chromatography, Plasma concentration, In vivo

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