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Effect of Cefradine on pharmacokinetics of baicalin in rats in vivo

Peng Jin-nian

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Abstract

Objective To study the effect of oral Cefradine on pharmacokinetics of baicalin in rats in vivo. Methods The rats were divided into two groups: one was supplied with baicalin individually and the other was supplied with the combination of Cefradine and baicalin. Plasma concentrations of two groups were detected by HPLC with electrochemical detection (ECD). The pharmacokinetic parameters were calculated by statistical analysis and compared. Results The pharmacokinetic parameters of combination administration group were C_ max (782.63±469.37) ng/mL, AUC_ 0-24 h (8 407.86±3 476.14) ng/mL·h; while the individual administration group of baicalin was C_ max (2 645.62±601.42) ng/mL, AUC_ 0-24 h (28 952.90 ±5 731.42) ng/mL·h. Conclusion The main pharmacokinetic parameters show significant difference between the two groups (P0.05). Taking Cefradine orally influences the plasma concentration of baicalin within an ideal range.

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Objective To study the effect of oral Cefradine on pharmacokinetics of baicalin in rats in vivo. Methods The rats were divided into two groups: one was supplied with baicalin individually and the other was supplied with the combination of Cefradine and baicalin. Plasma concentrations of two groups were detected by HPLC with electrochemical detection (ECD). The pharmacokinetic parameters were calculated by statistical analysis and compared. Results The pharmacokinetic parameters of combination administration group were C_ max (782.63±469.37) ng/mL, AUC_ 0-24 h (8 407.86±3 476.14) ng/mL·h; while the individual administration group of baicalin was C_ max (2 645.62±601.42) ng/mL, AUC_ 0-24 h (28 952.90 ±5 731.42) ng/mL·h. Conclusion The main pharmacokinetic parameters show significant difference between the two groups (P0.05). Taking Cefradine orally influences the plasma concentration of baicalin within an ideal range.

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Available abstract

Objective To study the effect of oral Cefradine on pharmacokinetics of baicalin in rats in vivo. Methods The rats were divided into two groups: one was supplied with baicalin individually and the other was supplied with the combination of Cefradine and baicalin. Plasma concentrations of two groups were detected by HPLC with electrochemical detection (ECD). The pharmacokinetic parameters were calculated by statistical analysis and compared. Results The pharmacokinetic parameters of combination administration group were C_ max (782.63±469.37) ng/mL, AUC_ 0-24 h (8 407.86±3 476.14) ng/mL·h; while the individual administration group of baicalin was C_ max (2 645.62±601.42) ng/mL, AUC_ 0-24 h (28 952.90 ±5 731.42) ng/mL·h. Conclusion The main pharmacokinetic parameters show significant difference between the two groups (P0.05). Taking Cefradine orally influences the plasma concentration of baicalin within an ideal range.

Key concepts: Baicalin, Pharmacokinetics, Pharmacology, In vivo, Plasma concentration, Oral administration, Chemistry, Significant difference

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