Colposcope Combined with Cervical Conization for the Early Diagnosis of Cervical Cancer

Objective To evaluate the value of colposcopy combined with cervical conization for the early diagnosis of cervical cancer.Methods A total of 604 cases who were diagnosed with high grade cervical intraepithelial neoplasia(CINⅡ,Ⅲ)or cervical cancer by pathology in our hospital between January 2005 to December 2011 were collected.Their clinical pathological data were retrospectively studied.Results Colposcopy and biopsy suggested 35 cases of low-grade cervical lesions,306 cases of CINⅡ,189 cases of CINⅢ and 74 cases of invasive cervical carcinoma(ICC).A total of 371 cases of CIN received cervical conization,and 19 cases were diagnosed as ICC;49 CIN cases received hysterectomy,and 5 cases of ICC were found.Some CIN Ⅲ cases were further treated with hysterectomy after cervical conization,and no upgraded cases were found.The accuracy rate of colposcopy and biopsy in detecting high grade CIN was 53.9%(123/228) and 72.6%(114/157) for CINⅡand CINⅢ,respectively.Twenty-four cases of ICC were missed in the diagnosis by colposcopy and biopsy,and they were diagnosed as 1 case of low-grade cervical lesions,2 cases of CINⅡ and 21 CINⅢ.The higher the lesion grade,the higher the rate of missed diagnosis(P0.01).Ninety-three cases of ICC were detected by colposcopy combined with cervical conization with the detection rate of 94.9%,and 80.6%(75/93) of them were early invasive carcinoma.Conclusion Colposcopy combined with cervical conization has the potential to provide accurate and early diagnosis,and can avoid missed diagnosis of concealed cervical cancer.