Effects of single adding dose of rovastatin on perioperative cardiac markers of percutaneous coronary intervention

OBJECTIVE To investigate whether adding 20mg rovastatin prior to percutaneous coronary intervention(PCI)can efficiently reduce the incidence of perioperative cardiac markers.METHODS A total of 150 patients with stable angina pectoris who underwent selective PCI were enrolled in this study and randomized into two groups:the rovastation group and the control group.The rovastatin group was given a single loading of 20mg rovastatin 12 hours before receiving PCI on top of routine medical therapy.The control group was treated with routine medication alone.TnI and CK-MB were checked for all patients after PCI.RESULTS Post-operative CK-MB and TnI levels in rovastatin group were significantly lower than those in control group.Moreover,the number of patients with CK-MB and tnI level 3 times above the normal value in rovastatin group was significantly less than that in control group.CONCLUSION The level of cardiac markers and corresponding incidence of myocardial infarction could be reduced by a single high loading dose of 20mg rovastatin given prior to PCI in stable angina patients with normal cardiac markers.