Clinical comparison of different doses of dezocine combined with propofol in anesthesia during artificial abortion

Objective To explore the effect of propofol combined with different dosages of intravenous dezocine on the body reaction of the dilated cervix during painless artificial abortion, and to provide the safety and reliability of target controlled infusion(TCI) of propofol combined with sing intravenous dezocine on the clinical basis. Methods Eighty patients undergoing artificial abortion were randomly divided into 4 groups with 20 cases in each. Patients were treated with small pot of intravenous dezocine(group A 100 μg/kg, group B 150 μg/kg, group C 200 μg/kg, group D 250 μg/kg). 3.5μg/ml propofol was continuously pumped into the effect parts at the target concentration 15 min later. Results The difference of MAP and HR of group A, B in which dezocine injection(T1) was followed by propofol after cervical dilatation(T4)were significantly higher than those of group C and D(P 0.05). Twelve cases had grade Ⅱ body reaction in group A and B respectively, which was significantly more frequent than group C and D(P 0.05). The recovery time [(2.53±0.18)min] in group C was significantly shorter than those in other groups(P 0.05); the number of patients with dizziness in group D was significantly greater than those in other groups(P 0.05). Visual Analogue Scale/Score(VAS) in group C and D were lower than those in group A and B(P 0.05). Conclusion Small pot of intravenous dezocine(200 μg/kg) and infusion of effective concentration of propofol(3.5 μg/ml) in the anesthesia of artificial abortion can reduce body movement after cervical dilatation, shorten the recovery time, and provide better postoperative analgesia effect.