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The Serum Bactericidal Activity of Gatifloxacin

Fei Pei

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Abstract

OBJECTIVE To evaluate antibacterial activity in vivo and in vitro of gatifloxacin. METHODS Minimal inhibitory concentration (MIC) and serum bactericidal titer (SBT) were determined by agar disk dilution method and microplate method respectively. RESULTS MIC90 of gatifloxacin against G+ bacterium was twice to fourfold as that of levofloxacin. MIC of gatifloxacin against G- bacterium was same as levofloxacin. The percentage of peak SBT≥1 : 8 with gatifloxacin aagainst Staphylococcus aureus, S. epidermidis, Klebsiella pneumoniae, En-terobacter cloatae was 100%, 90%, 100% and 100%, respectively and against Enterococcus faecalis ,Escherichia coli, Pseudomonas aeruginosa was 50%, 60%, 50%, respectively. CONCLUSIONS The antibacterial activity in vivo and in vitro of gatifloxacin against common bacterium is strong, especially that against G + bacterium is stronger than other quinolones.

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What this paper is about

OBJECTIVE To evaluate antibacterial activity in vivo and in vitro of gatifloxacin. METHODS Minimal inhibitory concentration (MIC) and serum bactericidal titer (SBT) were determined by agar disk dilution method and microplate method respectively. RESULTS MIC90 of gatifloxacin against G+ bacterium was twice to fourfold as that of levofloxacin. MIC of gatifloxacin against G- bacterium was same as levofloxacin. The percentage of peak SBT≥1 : 8 with gatifloxacin aagainst Staphylococcus aureus, S. epidermidis, Klebsiella pneumoniae, En-terobacter cloatae was 100%, 90%, 100% and 100%, respectively and against Enterococcus faecalis ,Escherichia coli, Pseudomonas aeruginosa was 50%, 60%, 50%, respectively. CONCLUSIONS The antibacterial activity in vivo and in vitro of gatifloxacin against common bacterium is strong, especially that against G + bacterium is stronger than other quinolones.

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Available abstract

OBJECTIVE To evaluate antibacterial activity in vivo and in vitro of gatifloxacin. METHODS Minimal inhibitory concentration (MIC) and serum bactericidal titer (SBT) were determined by agar disk dilution method and microplate method respectively. RESULTS MIC90 of gatifloxacin against G+ bacterium was twice to fourfold as that of levofloxacin. MIC of gatifloxacin against G- bacterium was same as levofloxacin. The percentage of peak SBT≥1 : 8 with gatifloxacin aagainst Staphylococcus aureus, S. epidermidis, Klebsiella pneumoniae, En-terobacter cloatae was 100%, 90%, 100% and 100%, respectively and against Enterococcus faecalis ,Escherichia coli, Pseudomonas aeruginosa was 50%, 60%, 50%, respectively. CONCLUSIONS The antibacterial activity in vivo and in vitro of gatifloxacin against common bacterium is strong, especially that against G + bacterium is stronger than other quinolones.

Key concepts: Gatifloxacin, Enterococcus faecalis, Staphylococcus epidermidis, Microbiology, Minimum inhibitory concentration, Levofloxacin, Antibacterial activity, Klebsiella pneumoniae

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