Effects of Fluoride on the Metobolism of Iodine in Thyriod in Chicken

In attempt to investigate the effects of fluoride on the metabolism of iodine in thyriod in chicken , 250 one day chicks were randomly divided into 5 groups ,50 for each . Group I was the control , and other four groups ,groupII,III,IV,V were fed the diets containing 500,1 000,1 500,2 000 mg/kg of fluorine as sodium fluoride, respectively, for 150 days. The contents of serum fluorine and iodine in thyroid were determined at every other 30 days, and the clinical manifestations of fluorosed chicks were observed everyday. The results showed as follows: The animal patterns of chick fluorosis were successfully established; The content of iodine in diet is normal;Compared with the control group, the content of iodine in thyroid in all fluorosed groups decreased ,moreover, showed a significant dose effect and time effect correlation .The content of serum F significantly correlated with the contents of iodine in thyroid, and the correlative coefficients were r=-0.814, and P0.01; In conclusion, Ingesting excessive fluoride obviously inhibited the functions of intaking thyroid and accumulating iodine,disturbed the metabolism of iodine, furthermore ,injured the structure and function of thyroid.