2011•China Occupational MedicineRequires access
Effects of formaldehyde exposure on airway hyperresponsiveness and lung pathological changes in rat model of asthma
Yuan Xi-zhe
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Abstract
Objective To investigate the effects of formaldehyde exposure on airway hyperresponsiveness and changes of the lung pathology in rat model of asthma.Methods 40 Wistar rats were randomly divided into 4 groups,a control group(group A),an animal model group(group B),a 12.5 mg/m3 formaldehyde group(group C)and a 25.0 mg/m3 formaldehyde group(group D).The mice were exposed for 2 weeks.RL of each rat was evaluated for 30 min.Levels of IgE and interleukin-13(IL-13)in serum were detected by ELISA.Results ① RL,IgE concentration and expressions of IL-13 in group B,C and D were higher than that of group A(F=178.312,P0.01).RL,IgE concentration and expressions of IL-13 in group C and D were higher than those of group B(P0.01).②RL,IgE concentration and expressions of IL-13 in group D were higher than those of group C(P0.01).③Lung pathological examination showed epithelial shedding,infiltration of inflammatory cells in peribronchial area and fibrosis on the basement membrane.Conclusion Exposure to formaldehyde may exacerbate airway hyperresponsi-veness and inflammation in rat model of asthma.