Effect of Magnesium on Airway Remodeling of Bronchial Asthma in Guinea Pigs

Objective To explore the effects of magnesium on the airway remodeling of bronchial asthma in guinea pigs. Methods 50 guinea pigs were divided into 5 groups:normal group(A group),asthma model group(B group),continued asthma model group(B1 group),high magnesium group(B2 group),low magnesium group(B3 group).Remodeling models of asthma were established with ovalbumin. Results ①In B group,concentration of magnesium in serum were significantly decreased and thicknesses of airway mucosa,base membrane,smooth muscle were significantly increased compared with A group(P0.05,0.01).②In B1 group,concentration of magnesium were significantly decreased and thicknesses of airway walls were significantly increased compared with B group(P0.05,0.01).③Thicknesses of airway walls in B2 group were smaller than those of B1 group(P0.05).④Thicknesses of airway walls in B3 group were greater than those of B1 group(P0.05). Conclusion Magnesium can regulate the airway remodeling of bronchial asthma in guinea pigs.