Effects of 5-HT and electrolytes on the airway remodeling of bronchial asthma in guinea pigs

AIM: To explore the effects of 5-HT and electrolytes on the airway remodeling in guinea pigs with bronchial asthma.METHODS: 70 guinea pigs were divided into 7 groups: control group,model group,continued model group,5-HT group,anti-5-HT group,high Mg~(2+) group,low Mg~(2+) group.Remodeling model was established with ovalbumin.RESULTS: ① In model group,5-HT of serum and thickness of airway walls were significantly increased compared with control group(P0.05,P0.01).② In continued model group,5-HT and thickness of airway walls were significantly increased compared with model group(P0.05,P0.01).③ In 5-HT group,thicknesses of airway walls were significantly increased compared with continued model group(P0.05).④ In anti-5-HT group,thicknesses of airway walls were significantly decreased compared with continued model group(P0.05).⑤ In high Mg~(2+) group,thicknesses of airway walls were significantly decreased compared with continued model group(P0.05).⑥ In low Mg~(2+) group,thickness of airway smooth muscle was significantly increased compared with continued model group(P0.05).⑦ With the aggravation or alleviation of airway remodeling,concentration of Ca~(2+) in serum was upward or downward.However,concentration of PO~(3-)_4 was downward or upward.⑧ Veriety of Na~+,K~+,Cl~-was no significant difference among groups.⑨ Concentration of 5-HT in serum was corrected with that of Ca~(2+).CONCLUSIONS: ① 5-HT mediates airway remodeling of asthma in guinea pigs whereas Mg~(2+) may play a regulatory role.② Increase in Ca~(2+) and decrease in PO~(3+)_4 may promote the airway remodeling of asthma whereas Na~+,K~+,Cl~-may not play any role.③ Concentration of 5-HT in serum was corrected with that of Ca~(2+) in airway remodeling of asthma.