Clinical significance of detection of immunity function in myelodysplasticsyndrome patients

Objective To evaluate the clinical significance and changes of immunity function in patients with myelodysplastic syndrome(MDS).Methods Flow cytometry was adopted to examine peripheral blood lymphocyte subpoplulations among 20 healthy volunteers and 23 MDS patients,who were confirmedly diagnosed but not yet treated.The ratios of lymphocyte subpoplulations include CD3+T cells,CD3+CD4+T cells,CD3+CD8+T cells,CD4+/CD8+,B cells(CD3-CD19+) and NK cells-subsets.Results Compared with the healthy controls,the T lymphocyte counts of peripheral blood were obviously decreased and the ratio of subpopulation was imbalanced,which was mainly represented by the reduction of CD4+ T cell subpopulations.In addition,the positive rate of CD8+inhibitory T cells was increased;the proportion of CD4+T cells and CD8+T cells was inverted;With the effect of killing tumor cells,NK cells and B cells were significantly lower than normal person.Conclusion Under the circumstances of the decreased immune function,detection of lymphocyte subpopulations of peripheral blood among MDS patients could be used in immunological surveillance.And there was a close relationship between immune function and the genesis and development of MDS.