Changes in the lymphocyte subgroup after TACE, THPP of primary hepatic carcinoma

Purpose: Observe the varities of lymphocyte subgroup of patients suffering from primary hepatic carcinoma ( PHC) during the treatment by hepatic arterial chemoembolization (TACE) and Hyperthemia Peritoneal Perfusion (THPP). Methods: Twenty seven patients were treated with TACE and THPP a week after TACE. We tested for lymphocyte subgroup three times with the flow cytometry (FCM) for pre-TACE, post-TACE and THPP a month later. The control group, twenty seven patients, were also tested for lymphocyte subgroup three times with the TACE. Results: The lymphocyte subgroup among the patients suffering from PHC were disordered. CD4+,CD4+/CD8+.CD19+NK+ were decreased, (P0. 05). CD3+, CD8+.remained unchanged. Post-TACE, CD4+,CD4+.CD8+,CD19+ , NK+ decreased significently (P 0. 05). The control group remained unchanged (P 0. 05). Conclusions: Immunologic status of the patients with PHC were signifficently suppressed. The TACE made them lower. After the THPP, immunologic status of lymphocyte subgroup patients were increased significently.