Effect of concentration of serum luteinizing hormone in late follicle phase on the outcome of in vitro fertilization after superovulation by short-term protocol

Objective To evaluate the effect of sersum luteinizing hormone (LH) level in late follicle phase on the outcome of in vitro fertilization (IVF). Methods From May 2006 to Oct.2006 the outcome of 212 infertile normal gonadotropic women in Peking University Third Hospital who were performed IVF/ICSI (intracytoplasmic sperm injection) treatment on was retrospectively analyzed. The protocol of controlled ovarian hyperstimulation was short-term protocol.The aim was to test the relationship between the IVF outcome and the serum LH level of HCG Day. Fertilization, pregnancy, and spontaneous abortion rates were also evaluated according to a threshold value serum LH of 1.58 IU/L, group A (LH 1.58 IU/L) and B (LH ≥1.58 IU/L ).Results The clinical pregnancy rate of B group was significantly higher than A group. The total dosage of Gn and days to achieve stimulation in A group were significantly more than B group(0.01).The estradiol and progesterone levels on the day of HCG administration in A group were significantly lower than B group. The number of oocytes retrieved in A group was significantly more than B group. The fertilization rate and high-quality embryos rate between the two groups ware similar in statistics. The multiple birth rate and spontaneous abortion between two groups ware similar in statistics. Conclusion Low endogenous LH concentrations (1.58IU/L) in the late follicular phase of an IVF cycle are associated with significantly lower clinical pregnancy rate. It may be associated with more oocytes harvesting and lower E2 and P level.