The Effect of Serum LH Levels on Pregnancy Outcome in Women Undergoing IVF with Long Protocols

Objective The aims of this study were to assess the effect of serum LH levels on pregnancy outcome in women undergoing IVF with long protocols. Methods A retrospective study that included 274 cycles was preformed in this study.Serum LH levels were measured on the day of HCG administration.Results The receiver operating characteristic(ROC) analysis was used to explore the influence of serum LH levels and Gonadotrophin doses to pregnancy results.It showed that there was a significant correlation between serum LH levels on the day of HCG administration and pregnancy rates.Compared with group with more than 1.05 IU/ml serum LH levels,the group with less than 1.05 IU/ml serum LH levels revealed a significantly lower pregnancy rate(37.7% vs 52.5%,P0.001).Meanwhile,the higher doses of Gn,the longer days of stimulation were observed.Consequently,good embryo rates,implantation rates,clinical pregnancy rates decreased significantly,and early abortion rate increased.Other parameters including E2 concentrations on the day of HCG administration,the numbers of retrieval oocytes,fertilization rates,cleavage rates presented no statistical difference.Conclusion During long protocol,the LH levels with less than 1.05 IU/ml on the day of HCG administration implied that the hypothalamus was suppressed excessively,it would lead to the lower pregnancy and implantation rate and higher early abortion rate.