Compared Study on Tramadol and Fentanyl via Subcutaneous PCA Following Cardiac Surgery

Objective:To evaluate the efficacy and safety of tramadol and fentanyl for releasing pain after cardiac surgery with subcutaneous PCA(PCSA).Methods:Twenty_one patients with preoperative cardiac funcˉtion of ASA I～III were randomly divided into two groups after cardiac surgery which included tramadol group(n=10)and fentanyl group(n=11).The mixture of tramadol(10g/L)and lidocaine(10g/L),fentanyl(25mg/L)and lidocaine(10g/L)were respectively given in tramadol group and fentanyl group.PCSA setting:loading dose of2mL,bolus dose of1mL,hour limit of8mL/h,and lockout time of5minutes were set.Patients with pain score above3on Visual Analog Scale8hours after extubation and without any contraindications of PCA were enrolled in this study.The following variables were recorded at intervals of12,24,36,and48hours after extubation.Results:There was a significant difference in onset of analgesia and drug dose at12hours between tramadol group and fentanyl group(P0.05).There was no significant difference in sexual distribution,status of drink,incidence of nausea and vomiting,level of education,analgesia efficacy,sedation,patient satisfaction,recovering time of gut motility,and postoperative hospitalization(P0.05).Conclusion:There was no signifiˉcant difference in monitoring target and the incidence of side effect between two groups.The present study confirmed that PCSA administration of tramadol could provide effective analgesia following cardiac surgery.