Observations on the effect of insulin sensitizer on patients with type 2 diabetic of different insulin levels

Objective To investigate the effect of insulin sensitizer on patients with type 2 diabetic of different insulin levels.Methods Sixty-eight patients with type 2 diabetes of different insulin levels were given rosiglitazone maleate for 3 months.Fasting and 2 h postprandial plasma glucose and C pepdide were measured before and after treatment.Results Contrasted at pre-and post-treatment,the datas at post-treatment of the fasting or postprandial plasma glucose and C pepdide had a great difference than before in the group of hypersecretion and normal secretio(P0.01).Fasting C pepdide decreased in both groups of baseline lower secretion group(P0.05),of which the postprandial plasma glucose and C pepdide decreased more significantly in L-H group but fasting glucose did not decrease significantly.While in L-L group,there were no significant changes except the significant decrease in fasting C pepdide(P0.05).Conclusion Insulin sensitizer is more suitable for patients with type 2 diabetes of higher or normal insulin secretion.It can increase the sensitivity to insulin,which is beneficial to the blood glucose control and decrease in hyperinsulinmia.But its effect on diabetic patients with lower insulin secretion is not obviouse.