Resolution Met COMT gene Polymorphism and Endometriosis-associated
Shi Caige
Abstract
Shi Caige
Abstract
objective Explore Met COMT gene polymorphism and endometriosis-associated dependencies.M ethods Observer Group in this study,60 cases endometrium of patients,were admitted to our hospital between June 2010 to June 2012.With 40 cases in the control group of non-exclusive and adenomyosis female had COMT gene type using the PCR-RFLP method,Recallrelated information.Results Observer Group pure and wild-type(G/G) of hybrid genotypes,mutations(G/A) genotypes,homozygous mutation frequencies compared with the control group difference was not obvious meaning(P0.05).Two sets of g allele frequen cies(Observer Group 72.9%,control 27.1%) with the a allele frequency(Observer Group 70%,control group 30%) are not significantly different(P0.05).COMT C/G(OR=1),G/A(OR=0.516,95%CI 0.186-1.442),A/A(OR=0.451,95%CI=0.166-1.234),three genotypes relative risk analysis no significant differences(P0.05).Prompting the endometrium of patients with no obvious correla tion between the polymorphism of COMT gene.C onclusion Endometrium of patients and no correlation between polymorphism of COMT gene Met,could serve as a reference in clinical treatment.
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objective Explore Met COMT gene polymorphism and endometriosis-associated dependencies.M ethods Observer Group in this study,60 cases endometrium of patients,were admitted to our hospital between June 2010 to June 2012.With 40 cases in the control group of non-exclusive and adenomyosis female had COMT gene type using the PCR-RFLP method,Recallrelated information.Results Observer Group pure and wild-type(G/G) of hybrid genotypes,mutations(G/A) genotypes,homozygous mutation frequencies compared with the control group difference was not obvious meaning(P0.05).Two sets of g allele frequen cies(Observer Group 72.9%,control 27.1%) with the a allele frequency(Observer Group 70%,control group 30%) are not significantly different(P0.05).COMT C/G(OR=1),G/A(OR=0.516,95%CI 0.186-1.442),A/A(OR=0.451,95%CI=0.166-1.234),three genotypes relative risk analysis no significant differences(P0.05).Prompting the endometrium of patients with no obvious correla tion between the polymorphism of COMT gene.C onclusion Endometrium of patients and no correlation between polymorphism of COMT gene Met,could serve as a reference in clinical treatment.
Key concepts: Adenomyosis, Genotype, Medicine, Allele, Endometriosis, Internal medicine, Correlation, Gastroenterology