Midazolam,Propofol,Fentanyl induced by tracheal intubation on hemodynamics

Objective:To investigate the midazolam-propofol-fentanyl-rocuronium induced by tracheal intubation on hemodynamics.Methods:line 40 cases of thyroid surgery patients were randomly divided into 2 groups:midazolam-propofol-fentanyl-rocuronium group(group A) and normal saline-propofol-fentanyl-rocuronium group(group B),20 cases of each group,anesthesia induction,when group A sequential intravenous midazolam 0.06～0.08 mg/kg(10 s),3 min after the intravenous injection of propofol 2 mg/kg (10 mg/5 s),fentanyl 2.5～4.0μg/kg(10 s),rocuronium 0.6～1,0 mg/kg(5 s),Group B first intravenous injection of normal saline 3 ml,3 min later by the same method after the intravenous injection of propofol-fentanyl-rocuronium induced combined.Two groups were observed before induction,induction, intubation,skin incision the HR,SBP,DBP,MAP changes,propofol dosage and side effects.Results: The 2 groups of patients with HR at all observation points was no significant difference(P0.05).Group A in the immediate induction of SBP,DBP,MAP were higher than those in group B(P0.05);in immediate intubation and skin incision group A of SBP,DBP,MAP were lower than group B(P0.05). Group comparison showed that A,B 2 groups in the induction of HR immediately before induction were significantly more elevated(P0.05),then group A HR gradually decreased(P0.05),while the group B with smaller HR changes(P0.05);SBP,DBP,MAP in group A showed no significant difference with contsol(P0.05).In group B SBP,DBP,MAP and induced in the induction before intubation compared with immediate-induced differences were statistically significant(P0.05).Group 2 did not occur after delayed recovery in the amount of anesthesia compared with propofol during maintenance of the difference was not significant(P0.05).Conclusion:Midazolam-propofol-fentanyl-rocuronium group hemodynamic parameters induced by a more stable and inhibit the cardiovascular side effects than the normal saline-propofol-fentanyl-rocuronium group.