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[Effects of prostaglandin E1 on hepatic function and hepatofibrosis in patients with chronic hepatitis B].

Gong Hy, Wang Kq, Tang Sg, Zhang Wj

Abstract

To search for an effective drug to cure patients with chronic hepatitis B. Twenty eight patients with chronic hepatitis B were treated with prostaglandin E1. The comprehensive indexes, including glutamic pyruric tranasaminase (GPT), serum total bilirubin (TBIL), total bile acid (TBA), hyaluronic acid (HA) and precollagen type III (PCIII), were examined before and after treatment. The levels of GPT, TBIL, TBA, HA, PCIII after 1 month of the treatment were significantly lower than those before the treatment (P < 0.05), there were significant differences between the treated and the controlled group patients with chronic hepatitis B (P < 0.05). The results suggest that the treatment with PGE1 might improve hepatic function, and resist the hepatic fibrosis in patients with chronic hepatitis B.

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Available abstract

Key concepts: Medicine, Gastroenterology, Hepatic fibrosis, Chronic hepatitis, Internal medicine, Hyaluronic acid, Hepatic function, Prostaglandin E1