Effect of fluoxetine combined with psychotherapy in the treatment of patients with post-stroke depression

Objective To study the effects of Fluoxetine combined with psychotherapy in treating post - stroke depression. Methods In this study,a total of 118 patients with post - stroke depression were divided into 2 groups randomly. Among all patients,59 patients were treated with psychotherapy(Control group) and other 59 patients were treated with Fluoxetine 20～40 mg every day combined with psychotherapy(Treatment group) for 8 weeks.HAMD and CSS were used to evaluate the symptoms improvement and side effects.Results After 8 weeks treatment,HAMD and CSS scores obviously decreased in two groups,but these scores in the treatment group were lower than those in the control group.There were significant differences in two groups(P 0.01).The total rate of effectual remedy for anti - depression and recovery neurological function were obviously higher in treatment group(93.2%,91.5%) than those in control group(81.36%,79.66%). Conclusion Fluoxetine combined with psychotherapy can obviously improve anti - depression and recovery degree of neurological function exceptionally in depressive hypokinesis symptoms,such as energy dissipated,ahedonia,thinking,speaking, taking action,improved more well,improved symptoms of depression more thoroughly,more significant activation of rehabilitation force.