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Study on Self-assembled Peptides to Depress Cell Apoptosis in Rat Experimental Acute Spinal Cord Injury

Xiaojun Zhao

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Abstract

Objective To explore self-assembly peptides characteristics to apoptosis following spinal cord injury. Methods Rat model of spinal cord injury was established. Apoptosis in the injured area was examined by using terminal deoxynucleotidyl-mediated nick-end labeling(TUNEL). Results The TUNEL positive cells were detected 2 hours post injury,the number of TUNEL-positive stain reached a maximum 8 hours after injury,and there were fewer TUNEL-positive cells detected in self-assembling peptide group(SAP group). Conclusions Self-assembly peptides do benefit to depress cell apoptosis in the spinal cord after injury.

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What this paper is about

Objective To explore self-assembly peptides characteristics to apoptosis following spinal cord injury. Methods Rat model of spinal cord injury was established. Apoptosis in the injured area was examined by using terminal deoxynucleotidyl-mediated nick-end labeling(TUNEL). Results The TUNEL positive cells were detected 2 hours post injury,the number of TUNEL-positive stain reached a maximum 8 hours after injury,and there were fewer TUNEL-positive cells detected in self-assembling peptide group(SAP group). Conclusions Self-assembly peptides do benefit to depress cell apoptosis in the spinal cord after injury.

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Available abstract

Objective To explore self-assembly peptides characteristics to apoptosis following spinal cord injury. Methods Rat model of spinal cord injury was established. Apoptosis in the injured area was examined by using terminal deoxynucleotidyl-mediated nick-end labeling(TUNEL). Results The TUNEL positive cells were detected 2 hours post injury,the number of TUNEL-positive stain reached a maximum 8 hours after injury,and there were fewer TUNEL-positive cells detected in self-assembling peptide group(SAP group). Conclusions Self-assembly peptides do benefit to depress cell apoptosis in the spinal cord after injury.

Key concepts: TUNEL assay, Apoptosis, Spinal cord, Spinal cord injury, Medicine, Biology, Neuroscience, Biochemistry

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