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2012•Journal of Clinical Medicine in PracticeRequires access

Expression and significance of MMP-11 mRNA in human gastric cancer tissues

P Chen

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Abstract

Objective To investigate the expression and clinical significance of matrix metalloproteinase-11(MMP-11) in human gastric cancer.Methods The MMP-11 m RNA expression was examined quantitatively by using real-time quantitative polymerase chain reaction on a cohort of human gastric cancer tissues(n=40) and corresponding adjacent tissues(n=40).Results The results of fluorescent quantitative-PCR showed that the expression level of MMP-11 mRNA in gastric cancer tissues were significantly higher than that of the adjacent tissues(P0.05)).However the expression of MMP-11 mRNA had no correlation with the age and gender of patients,differentiation and size of gastric cancer.Conclusion MMP-11 mRNA is over-expressed in gastric cancer tissues and significantly correlates with clinical prognosis,and may have an important role in gastric cancer development and disease progression.

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What this paper is about

Objective To investigate the expression and clinical significance of matrix metalloproteinase-11(MMP-11) in human gastric cancer.Methods The MMP-11 m RNA expression was examined quantitatively by using real-time quantitative polymerase chain reaction on a cohort of human gastric cancer tissues(n=40) and corresponding adjacent tissues(n=40).Results The results of fluorescent quantitative-PCR showed that the expression level of MMP-11 mRNA in gastric cancer tissues were significantly higher than that of the adjacent tissues(P0.05)).However the expression of MMP-11 mRNA had no correlation with the age and gender of patients,differentiation and size of gastric cancer.Conclusion MMP-11 mRNA is over-expressed in gastric cancer tissues and significantly correlates with clinical prognosis,and may have an important role in gastric cancer development and disease progression.

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Available abstract

Objective To investigate the expression and clinical significance of matrix metalloproteinase-11(MMP-11) in human gastric cancer.Methods The MMP-11 m RNA expression was examined quantitatively by using real-time quantitative polymerase chain reaction on a cohort of human gastric cancer tissues(n=40) and corresponding adjacent tissues(n=40).Results The results of fluorescent quantitative-PCR showed that the expression level of MMP-11 mRNA in gastric cancer tissues were significantly higher than that of the adjacent tissues(P0.05)).However the expression of MMP-11 mRNA had no correlation with the age and gender of patients,differentiation and size of gastric cancer.Conclusion MMP-11 mRNA is over-expressed in gastric cancer tissues and significantly correlates with clinical prognosis,and may have an important role in gastric cancer development and disease progression.

Key concepts: Medicine, Cancer, Matrix metalloproteinase, Messenger RNA, Clinical significance, Real-time polymerase chain reaction, Pathology, RNA

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Expression and significance of MMP-11 mRNA in human gastric cancer tissues — Research Paper | ScholarLens