Serum CA199 variance and its related factors in type 2 diabetic patients

Objective To investigate the variance of serum CA199 levels and its related factors in type 2 diabetic patients. Methods One hundred and eighty hospitalized type 2 diabetic patients were enrolled in the study and were divided into3 groups accordingtoHb A1 c levels: group A( Hb A1 C 7. 5%,n = 56),group B( Hb A1 C 6. 5%-7. 5%,n = 59) and group C( Hb A1 C 6. 5%,n = 65);and 60 healthy subjects were alsoenrolled as normal controls( group D). The levels of serum CA199,fastingblood glucose,glycosylated hemoglobin,fastinginsulin,fastingC-peptide,age,sex,body mass index,waist circumference,total cholesterol,triglyceride,high density lipoprotein cholesterol,lowdensity lipoprotein cholesterol and other variables were used for analysis. The levels of serum CAl99 were compared amongthe 4 groups,and the correlation of CA199 with other variables was analyzed with multiple linear regression. Results CA199 levels in groups A and B were significantly higher than groups C and D,and that of group A was the highest. Spearman relation analysis showed that the CAl99 level was positively correlated with FBG( r = 0. 179,P = 0. 016),Hb A1C( r = 0. 424,P 0. 001). M ultiple linear regression analysis showed that Hb AlC was the independent risk factor for increased CAl9( β = 0. 388,P 0. 001). Conclusion The low-level elevation of serum CA199 in type2 diabetic patients may be closely related tolong-term poor glucose control.