Preparation and optimization of propranolol hydrochloride matrix sustained-release pellets

Objective To study the preparation of matrix sustained-release pellets containing propranolol hydrochloride and its evaluation in vitro. Methods The pellets were prepared by extrusion-spheronization,central composite design-response surface methodology was applied to optimize the formulation and manufacturing process,which was characterized by cumulative release. Results Optimized formulation and processing parameter were 9.06% EC,48.03% octadecanol,22.91% MCC,absolute ethyl alcohol as wetting agent,extruded at 30 r·min-1 and spheronized at 1 377 r·min-1 for 40 min. Conclusions Drug release of propranolol hydrochloride matrix sustained-release pellets in vitro is sustained and stable.