The Functional Change of β-cell in Cases of Diabetes Mellitus II with Hypertension

Objective:To study the changes of insulin seretion in diabetes mellitus Ⅱ with and without hypertension. Methods:298 cases of diabetes mellitus Ⅱ were divided into two groups according to their blood pressure. 95 cases were selected in hypertension group, and 203 cases were in control group. The oral glucose tolerant tests (OGTT) and insulin releasing test were performed to compare the levels of glucose and insulin in two groups.Homa model were used as IR,HBCI and IAI index,to evaluate insulin resistance and β cell function. Results:The fasting blood suger and insulin levels in hypertension group were significant higher than those in control group( P 0.01). The obesity patients in the two groups showed a significant insulin resistance as compared to those of non obesity patients ( P 0.01).Conclusion :There is a significant insulin resistance and disorder of β cell function in diabetes mellitus Ⅱ with hypertension. The obesity may increase the insulin resistance.