Value of dynamic enhanced MRI on differential diagnosis of benign and malignant breast lesions

Objective To evaluate diagnostic value of dynamic enhanced MRI in differentiation of benign from malignant breast lesions.Methods Dynamic enhanced scanning was performed in 80 females with breast lesions,including invasive ductal carcinomas(n=22),invasive lobularcarcinomas(n=12),medullary carcinoma(n=6),ductalcarcinomasitu(n=4),fibroadenoma(n=20),inflammation(n=5),lobular proliferate(n=11).Eighty cases underwent MR T1WI/SPIR,T2WI/SPIR.All of cases were examined with a 3D dynamic enhancement scan.The parameters for evaluation in dynamic enhanced MRI included lesion's morphological features,early enhancement rate and time-signal intensity curve pattern.Results Significant difference existed in the morphological features,early enhancement rate,and time-signal intensity curve pattern between malignant and benign lesions(χ2=31,20.2,51.6,P0.001).The sensitivity,specificity and accuracy of lesion's morphological features were 68.2%(30/44),77.8%(28/36),72.5%(58/80)respectively;The sensitivity,specificity and accuracy of early enhancement rate were 72.7%(32/44),77.8%(28/36),75%(60/80)respectively;The sensitivity,specificity and accuracy of time-signal intensity curve were 86.4%(38/44),88.9%(32/36),87.5%(70/80)respectively;The sensitivity,specificity and accuracy of using their combined criteria were 95.4%(42/44),94.4%(24/36),and 95%(76/80)respectively.Conclusion The combined criteria of morphological features,early enhancement rate and time-signal intensity curve pattern has great value in differential diagnosis between malignant and benign lesions.