Efficacy observation of invasive-non-invasive mechanical ventilation sequential therapy combined with aerosol inhalation in acute exacerbation of chronic obstructive pulmonary disease with respiratory failure

Objective To investigate the clinical efficacy of invasive-non-invasive mechanical ventilation sequential therapy combined with aerosol inhalation in acute exacerbation of chronic obstructive pulmonary disease(AECOPD) with respiratory failure.Methods 84 cases patients with CAEOPD combined respiratory failure and required intubation and mechanical ventilation were randomly divided into observation group(42 cases) and control group(42 cases) .All patients were given anti-infection,spasm,asthma,cough,phlegm,prevent complications,maintain homeostasis,nutritional support,treatment,trachea intubation-add breath-ing mach-ine synchronized intermittent mandatory ventilation+with pressure support ventilation(SIMV+PSV) mode of ventilation.In the pulmonary infection control window appears,unplug the observed of endotracheal intubation,used non-invasive nasal mask ventilation,and gradually reduce ventilator support parameters,until a successful off-line.Control group continued invasive ventilation,also gradually reduced ventilator support until the off-line success.Recorded off-line heart rate,respiratory rate,arterial oxygen pressure(PaO2) ,arterial blood pressure of carbon dioxide partial pressure(PaCO2) and pH of two groups,compared invasive ventilation time,the total mechanical ventilation time,length of stay and the incidence of ventilator-associated pneumonia(VAP) .Results Invasive ventilation time,the total mechanical ventilation time,length of stay of observation group were shorter than those of control group,there were significant difference(P0.05) .The incidence of VAP of observation group(7.1%) was lower than that of control group(35.7%) ,the difference was statistically significant(P0.05) .Conclusion Invasive-non-invasive mechanical ventilation sequential therapy in AECOPD,can reduce the invasive ventilation time and length of stay,reduce the incidence of VAP,is worthy of clinical application.