The study and clinical significance on the expression of sulfotransferase1A1, estrogen receptor a, estrogen receptor β, progesterone receptor in uterine leiomyoma and its clinical significance.

Objective To examine the expression of sulfotransferases1A1、estrogen receptor α,estrogen receptor β and progesterone receptor in uterine leiomyoma tissue,normal myometrium out of uterine leiomyoma tissue and normal myometrium tissue.Analysis the correlative expression of them.Methods Immune histochemistry(streptobacteria anti organism protein-peroxidase staining)was used to detect the expressions of SULT1A1,ERα,ERβ and PR in uterine leiomyoma tissue,normal myometrium out of uterine leiomyoma tissue and normal myometrium tissue.Using spss 11.0 software to do statistic analysis.Results The expression of SULT1A1 protein in normal myometrium tissues far away the wrapping membrane of myoma and in normal myometrium tissue is obvious higher than in uterine leiomyoma tissue(P 0.05).The expression of ERα、PR protein in uterine leiomyoma tissue is obvious higher than in normal myometrium tissues far away the wrapping membrane of myoma and in normal myometrium tissue(P 0.05),and have significantly negative relationship with the SULT1A1.Conclusion Estrogen receptor α and estrogen receptor β can promote the occurrence and development of hysteromyoma,sulfotransferases1A1 maybe play a suppression role in uterine myoma.