Expression and Significance of Id-1 in Human Gastric Cancer

Objective To investigate the expression of Id-1 in gastric cancer and its relationship with the clinicopathologic parameters,and to explore its clinicopathologic significance.Methods The expression of Id-1 was anayzed with immunohistochemistry SP technique in different gstric mucosa.Results The positive expression rates of Id-1 were 73.3% for gastric cancer tissues,21.7% for paracarcinoma tissues,and 6.7% for normal gastric mucosa.The expression of Id-1 was correlated with the degree of tumor differentiation,invasive depth,TNM stage and lymph node metastasis(P0.05),but had not significant difference for the elements of age,sex and tumor metastasis(P0.05).Conclusion The overexpression of Id-1 has great relationship with the gastric carcinogenesis,and Id-1 could be used as a reference indicator for invasion and metastasis of gastric cancer.