2005•The Korean Journal of Internal MedicineOpen access
The effect of propofol for conscious sedation during colonoscopy-A Prospective, Randomized Study
Hoon Cho, Yeong-Muk Kim, Ji-Hyeon Oh, Su-Jin Jeon, Jae-Hyeon Moon, Min-Hee Kim, Keum-Mi Park, Joon‐Sang Lee
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Abstract
Background:The objectives of this study were to assess propofol as sedative agents for colonoscopy in the safety and efficacy, compared with midazolam plus meperidine. Methods:120 patients undergoing colonoscopy in a prospective study were randomly assigned to one of three medication regimens. Patients in group A (n=42) received i.v. 25 mg of meperidine and 2.5 mg of midazolam. Patients in group B (n=41) received i.v. a median dose of 96.59 mg of propofol (range 40-180) and patients in group C (n=37) received i.v. 25 mg of meperidine and a median dose of 77.03 mg of propofol (range 40-150), administered by a nurse with endoscopist supervision. Endpoints were patient satisfaction, procedure and recovery times and complications. Results:The mean time to sedation was much faster in 2 groups using propofol (group A: 152105.9 sec, group B: 52.946.5 sec, group C: 5663.7sec; p