Diagnosis of Diffusion Weighted Imaging and inPeritumoral Edema of Brain Tumor

Objective To evaluate the potential of DWI in diagnosing of brain tumors and defining the tumor boundary by analysing theparameters obtained from peritumoral edema.Methods Ninty patients with brain diseases underwent routine,diffusion-weighted imaging.Comparisons of apparent diffusion coefficients(ADC),were done among normal,peritumoral edematous and tumoral tissues.The peritumoral signal abnormality was divided into two regions to allow investigation of whether ADC and metabolic ratios varies with distance of from the enhancing portion of the tumor.intracranial diseases were compared by using the ANOVA.All the statistical data were displayed as x±s,a P value of less than 0.05 indicated a statistically significant difference.Results ADC of immediate perifocal edema were prominently significant for differentiating high-grade gliomas from low-grade gliomas,metastases,meningiomas and inflammation(P0.05),As for high-grade glioma,the ADC of immediate peritumoral edema was lower than that of distant edema(P0.05),and the former is similar to the contrast-enhancing portion(P0.05).The ADC in immediate,distant peritumoral edema and solid portion of low-grade glioma could not distinguish from each other(P0.05).The ADC of immediate peripheral edema in patients with meningioma or inflammatory disease differed significantly from those of distant peripheral edema(P0.05).Conclusion The ADC in immediate perifocal edema enable distinction high-grade glioma from metastasis,meningioma and inflammatory disease.The ADCof immediate peritumoral edema was helpful to grade diagnosis of glioma.