Lentivirus Vectors and Gene Therapy by Using Hematopoietic Stem Cells

Lentivirus vector is an effective tool for the studies of gene therapy. The vector can not only effectively infect the target cells, hematopoietic stem cells (HSCs), but also make the genes carried by lentivirus vector integrate into genome of HSCs. In addition, foreign genes can express specially in HSCs by using the regulation elements in the lentivirus vector. In this article, we breifly reviewed the genomic characteristics of lentivirus vector, the development of the vector constructs, the infective ability to HSCs, the expression and regulation of genes carried by lentivirus vectors.