2005•Shandong yiyaoRequires access
Effect of taurine on neurogenesis in the dentate gyrus ofadult rat hippocampus after whole brain irradiation
Shijie Liu
Open publisher page 0 citations
Abstract
Objective: To observe the effect of taurine on neurogenesis in the dentate gyrus of adult rat hippocampus after whole brain irradiation.Methods: Adult male Wistar rats were subjected to 10Gy whole brain irradiation,apoptotic cells were quantified by TUNEL staining,proliferating cells were detected by Brdu labeling,the proportion of proliferating(BrdU~+) cells that co-express markers for mature neurons(NeuN) were determined by double immunostaining.Result: Twelve hours after irradiation,the number of TUNEL positive cells increased markedly in the dentate gyrus of adult rat,which could decreased by taurine administration(P0.05).In irradiated rats,taurine didn't alter BrdU positive cells reduction,but the proportion of BrdU positive cells that coexpress markers for mature neurons(NeuN) was elevated after taurine administration(P0.01).Conclusions: Taurine can inhibit apoptosis immediately after irradiation.It can also promote neurogenesis two months after irradiation,which may be related to its beneficial effects in protecting neurogenic niche.