Effect of Taurine on proliferation of neural stem cell after cerebral ischemia in rats.

Objective:To study the influence of Taurine on proliferation of neural stem cells after focal cerebral ischemia in rats and to explore the mechanism of taurine in treating ischemic brain injury.Methods:The model of middle cerebral artery occlusion was made by using opening ranium hot coagulation in 80 rats,who were divided randomly into normal group,sham operate group,model group and taurine group.Taurine was administrated once daily by i.p.in taurine group,and immunohistochemistry method was used to observe the number of Brdu positive cells on the 3rd,7th,14th and 21st day after ischemia.Results:There were Brdu positive cells in the cortex,hippocampal dentate gyrus(DG) and striatum at different time points after cerebral ischemia,and the number of Brdu positive cells in various brain regions increased significantly on the 7th day as(18.65 ±4.38),(25.63±3.58),(19.46 ±2.98) and having statistical significance(P0.05).It was also found that the number of Brdu positive cells in different phase taurine group was significantly more than that in the model group(P0.05).Conclusion:Taurine can increase the number of Brdu positive cells in some brain regions after focal cerebral ischemia,which has the important effect on treating ischemic brain injury.