A study on abnormality of coagulation and fibrinolytic system in patients with COPD at acute stage

Objective To discuss possible mechanism of chronic obstructive pulmonary disease(COPD)coagulation and fibrinolysis dysfunction.Methods Totally 47 healthy controls(Group A)and 38 cases of AECOPD(Group B)were chosen respectively.The plasma levels of vWF,Factor Ⅹ,TF,TFPI,TM,PC,tPA,PAI-1 and D-dimer were measured by ELISA method,and the blood AT-Ⅲ activity was measured by chromogenic assay.The cases of Group B were measured for RBC,WBC,PLT,PH,PaO2,PaCO2,HCO-3,PT,APTT,FBG,and so on.Results The plasma levels of vWF,TF,Factor Ⅹ,t-PA and D-dimer in Group B were significantly higher than those in Group A while TM and PC were significantly lower in Group B(P0.01).AT-Ⅲ,PAI-1 and TFPI levels in group A were not significantly different from Group B.Conclusion Abnormality of coagulation and fibrinolytic system exists in AECOPD.The application of prophylactic anticoagulant therapy,or even the prophylactic thrombolytic therapy,might become potential in the majority of AECOPD cases.