Clinical significance of detected coagulation and fibrinolysis function in severe acute pancreatitis

Objective To explore the clinical application value of detected coagulation and fibrinolysis function in the severity and prognosis of severe acute pancreatitis(SAP).Methods The levels of PT,APTT,FIB and D-D were detected in 106 patients with acute pancreatitis(AP) who were admitted in 24 h and 50 healthy people.All the patients were divided into two groups: mild acute pancreatitis(MAP) group(N=65) and SAP group(N=41).Results The level of PT,APTT,FIB and D-D in MAP group were higher than those in healthy controls,but there was no significant difference between them(P0.05),and they were significantly higher in SAP group than those in MAP group and control group(P0.05).The score of APACHE Ⅱ was positively correlative with the levels of PT,APTT,FIB and D-D in SAP group,and the correlation coefficient was 0.82,0.83,0.86 and 0.84,respectively(P0.05).There was significant difference on plasma PT,APTT,FIB and D-D between MODS group and non-MODS group(P0.05).Conclusion Detection of coagulation and fibrinolysis function can contribute to the severity and prognosis of SAP,and it has directive significance in preventing disease progression and reducing death rate.