2013•Acta Medicinae SinicaRequires access

Inhibitory effect of quercetin on proliferation of human breast cancer cell MCF-7

Wu Zhen

Abstract

Objective: To explore the effects of quercetin on cell cycle and cell proliferation,apoptosis of human breast cancer MCF-7 cell line.Methods: Quercetin was incubated with human breast cancer MCF-7 cell line in vitro,proliferation of MCF-7 cell line was detected by MTT experiment,cell cycle was measured by FCM,apoptosis was analyzed by Annexin Ⅴ/PI double staining.Results: Quercetin significantly inhibited the proliferation of MCF-7 cell line,high concentrations(≥ 50 μM),it promoted cell apoptosis,low concentrations(≤ 20 μM) it arrested MCF-7 cell line at S phase.Conclusion: Quercetin has the biological activity to arrest human breast cance MCF-7 cell line.

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Key concepts: MCF-7, Apoptosis, Cell growth, Cell cycle, Cell culture, Annexin, Quercetin, Cell